博士、校聘副教授、硕士生导师。学术兼职：安徽省环境诱变剂学会理事兼秘书、安徽省预防医学会卫生毒理专业委员会委员兼秘书。科学研究：主持国家自然科学基金面上项目、青年科学基金、安徽省自然科学基金面上项目、安徽省教育厅高校自然科学研究重点项目、安徽省高等学校省级优秀青年人才基金项目和bobapp安卓手机版 校级科学研究基金课题各1项，参与省部级以上课题多项；以第一作者（含共同第一作者）发表SCI论文14篇。获安徽省优秀硕士学位论文（2009年）、中华预防医学科技奖三等奖（2009年）和中华医学科技奖三等奖（2008年，2014年，2020年）、2021年校优秀共产党员、2011-2012学年校优秀班主任。

教育经历

2016/09-2019/06，bobapp安卓手机版 ，儿少卫生与妇幼保健学专业，博士研究生

2005/09-2008/06，bobapp安卓手机版 ，卫生毒理学专业，硕士研究生

1998/09-2003/06，bobapp安卓手机版 ，预防医学专业，本科生

工作经历

2020/01-至今，bobapp安卓手机版 ，公共卫生学院，校聘副教授

2008/09-2019/12，bobapp安卓手机版 ，公共卫生学院，助教、讲师

2015/04-2016/04，日本崇城大学，药学部，访问研究员

2003/08-2005/07，浙江省杭州市西湖区疾病控制中心，卫生监测科，公卫医师

主持科研项目

1. 国家自然科学基金面上项目，82173565，内质网应激降低α-酮戊二酸在孕期砷暴露致子代肝脏脂代谢重编程改变中的作用，55万元，在研，主持人。

2. 安徽省自然科学基金面上项目，2008085MH280，内质网应激感受器IRE1在细菌脂多糖干扰孕期母体胆汁酸代谢中的作用，12万元，在研，主持人。

3. 安徽省教育厅高校自然科学研究重点项目，KJ2020A0211，叶酸补充对孕期砷暴露致子代肝脏脂质沉积的保护作用，6万元，在研，主持人。

4. 国家自然科学基金青年科学基金项目，81001480，内质网应激在利福平致肝细胞脂质代谢紊乱中的作用，20万元，已结题，主持人。

代表性SCI论文（*通讯作者）

1. Bingdong Song#,Cheng Zhang#, Weirong Hu, Chunyu Guo, Zhengmei Xia, Wanxia Hu, Mingqiang Qin, Weiying Jiang, Jinwei Lv, Dexiang Xu, Shichen Zhang*, Jun Fang*, Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration,J Control Release,2021; 331: 350-363.

2. Cheng Zhang, Yu Gan, Jin-Wei Lv, Ming-Qiang Qin, Wei-Rong Hu, Zhi-Bing Liu, Li Ma, Bing-Dong Song, Jian Li, Wei-Ying Jiang, Jian-Qing Wang, Hua Wang, De-Xiang Xu*, The protective effect of obeticholic acid on lipopolysaccharide-induced disorder of maternal bile acid metabolism in pregnant mice,Int Immunopharmacol, 2020; 83: 106442.

3. Qian-Qian Chen^#,Cheng Zhang^#, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu*, Jian-Qing Wang*, Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor stf-083010 alleviates carbon tetrachloride induced liver injury and liver fibrosis in mice,Front Pharmacol, 2018; 9: 1344.

4. Da-Gang Zhang^#,Cheng Zhang^#, Jun-Xian Wang, Bi-Wei Wang, Hua Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Li Tao, Jian-Qing Wang, Xi Chen^*, De-Xiang Xu^*, Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation,Toxicol Appl Pharmacol, 2017; 314: 39-47.

5. Jun-Xian Wang^#,Cheng Zhang^#, Lin Fu, Da-Gang Zhang, Bi-Wei Wang, Zhi-Hui Zhang, Yuan-Hua Chen, Yan Lu, Xi Chen^*, De-Xiang Xu^*, Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases,Toxicol Lett, 2017; 265: 38-46.

6. Jia-Hui Huang^#,Cheng Zhang^#, Da-Gang Zhang, Lu Li, Xi Chen^*, De-Xiang Xu^*, Rifampicin-Induced Hepatic Lipid Accumulation: Association with Up-Regulation of Peroxisome Proliferator-Activated Receptor γ in Mouse Liver,PLoS One; 2016, 11(11): e0165787.

7. Ye-Fa Zhang^#, Wei He^#,Cheng Zhang^#, Xiao-Jing Liu, Yan Lu, Hua Wang, Zhi-Hui Zhang, Xi Chen^*, De-Xiang Xu^*, Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice,Toxicol Lett, 2014; 225(3): 445-453.

8. Jian-Qing Wang^#, Xi Chen^#,Cheng Zhang^#, Li Tao, Zhi-Hui Zhang, Xiao-Qian Liu, Yuan-Bao Xu, Hua Wang, Jun Li^*, De-Xiang Xu^*, Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice,Toxicol Appl Pharmacol, 2013; 266(2):307-316.

9. Cheng Zhang^#, Xi Chen^#, Ren-Min Zhu^#, Ying Zhang, Tao Yu, Hua Wang, Hui Zhao, Mei Zhao, Yan-Li Ji, Yuan-Hua Chen, Xiu-Hong Meng, Wei Wei^*, De-Xiang Xu^*, Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice,Toxicol Lett; 2012, 212(3): 229-240.

10. Xi Chen#,Cheng Zhang#, Mei Zhao, Chang-E Shi#, Ren-Min Zhu, Hua Wang, Hui Zhao, Wei Wei, Jia-Bin Li, De-Xiang Xu*, Melatonin alleviates lipopolysaccharide-induced hepatic SREBP-1c activation and lipid accumulation in mice,J Pineal Res, 2011; 51(4): 416-425.

11. Xi Chen#,Cheng Zhang#, Hua Wang, Juan Xu, Zi-Hao Duan, Ying Zhang, Tao Yu, Wei Wei, De-Xiang Xu*, Jian-Ming Xu*, Altered integrity and decreased expression of hepatocyte tight junctions in rifampicin-induced cholestasis in mice,Toxicol Appl Pharmacol, 2009; 240 (1): 26-36.

12. Xiang-Yun Li#,Cheng Zhang#, Su-Fang Wang, Yan-Li Ji, Hua Wang, Lei Zhao, De-Xiang Xu*, Maternally-administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species,Toxicol Lett, 2008; 176 (3): 169-177.

13. Xiang-Yun Li#,Cheng Zhang#, HuaWang, Yan-Li Ji, Su-FangWang, Lei Zhao, Xi Chen, De-Xiang Xu*, Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment,Toxicol Lett, 2008; 179 (2): 71-77.

14. Cheng Zhang,Xiang-Yun Li, Lei Zhao, Hua Wang, De-Xiang Xu*, Lipopolysaccharide (LPS) up-regulates the expression of haem oxygenase-1 in mouse placenta,Placenta, 2007; 28 (8-9): 951-957.